T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39
conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP–P2 …

Within tumors, some areas are less oxygenated than others. Since their home ground is
under chronic hypoxia, tumor cells adapt to this condition by activating aerobic glycolysis; …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

Tumors use several strategies to evade immunosurveillance. One such mechanism is the
generation of adenosine within the tumor microenvironment, which potently suppresses …

Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct
damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the …