Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage
in many medical settings, with substantial associated morbidities and mortalities. Among …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However,
FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making …

Drug-induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in
hospitalized patients and is associated with increased morbidity and mortality in both …

Candida albicans is part of the normal human flora but is most frequently isolated as the
causative opportunistic pathogen of candidiasis. Plant-based essential oils and their …

Amphotericin B is an antibiotic used as the “gold standard” in the treatment of life-
threatening fungal infections. Several molecular mechanisms have been proposed to …

This review examined a collection of studies regarding the molecular properties of some
polyene antibiotic molecules as well as their properties in solution and in particular …

Amphotericin B (AmB) is a potent polyenic antifungal agent with leishmanicidal activity. Due
to its low solubility and permeability in the gastrointestinal tract, AmB is usually administered …

Parenteral amphotericin B has been considered as first-line therapy in the treatment of
systemic fungal and parasitic infections, however its use has been associated with a number …