Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

Since the evolutionary discovery of RNA interference and its utilization for gene knockdown
in mammalian cell, a remarkable progress has been achieved in small interfering RNA …

Functional nanomaterials as nanodrugs based on the self‐assembly of inorganics,
polymers, and biomolecules have showed wide applications in biomedicine and tissue …

Studies on siRNA delivery have seen intense growth in the past decades since siRNA has
emerged as a new class of gene therapeutics for the treatment of various diseases. siRNA …

Current delivery strategies for cancer therapeutics commonly cause significant systemic side
effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor …

Introduction RNA interference (RNAi) using small interfering RNA (siRNA) is a promising
strategy to control many genetic disorders by targeting the mRNA of underlying genes and …

The site‐selective modification of biomolecules has grown spectacularly in recent years. The
presence of a large number of functional groups in a biomolecule makes its chemo‐and …

Mendelian genetics spark the century‐old revolution in genetic engineering. DNA structural
engineering may well spark a similar revolution in chemistry. The first few man‐made DNA …

Cell penetrating peptides (CPPs), and protein transduction domains (PTDs) of viruses and
other natural proteins serve as a template for the development of efficient peptide based …

Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as
powerful therapeutic compounds for targeting mRNAs and inducing their degradation …