Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver
disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are at the
highest risk for progressing to end‐stage liver disease. We constructed and validated a …

The 18 glycosyl hydrolase family of chitinases is an ancient gene family that is widely
expressed from prokaryotes to eukaryotes. In mammals, despite the absence of endogenous …

Background & Aims A number of genetic polymorphisms have been associated with
susceptibility to or protection against non-alcoholic fatty liver disease (NAFLD), but the …

Background & Aims: Histologic examination of a liver biopsy specimen is regarded as the
reference standard for detecting liver fibrosis. Biopsy can be painful and hazardous, and …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory
therapies, including corticosteroids, are of no benefit. The role of monocytes and …

A common clinical concern in patients with NAFLD is whether they have NASH or simple
steatosis and, more importantly, what the stage of fibrosis is and whether the level of fibrosis …