Uncovering the comprehensive catalytic mechanism for the activation of triplet O2 through
metal-free and cofactor-free oxidases and oxygenases remains one of the most challenging …

Alanine racemase (Alr) catalyzes the pyridoxal 5′-phosphate (PLP)-dependent
racemization between l-and d-alanine in bacteria. Owing to the potential interest in targeting …

Spin-labeled amino acids (SLAAs) are often used to determine intermolecular distances and
conformations in proteins via double electron–electron resonance. Currently available …

In this book chapter, we discuss the use of atomic models of the enzyme–substrate complex
and computational methods to explain stereocontrol in enzymatic reactions. After defining …

Spin labels are a useful tool towards the study of protein conformation and enable the
mapping of interactions between specific positions within these systems. Synthetic routes …