[HTML][HTML] The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

BAH Smith, CR Bertozzi - Nature reviews Drug discovery, 2021 - nature.com
Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles

MJ Ryan, HJ Dudash, M Docherty… - The Journals of …, 2008 - academic.oup.com
This study compares changes in the pro-oxidant production and buffering capacity in young
and aged skeletal muscle after exposure to chronic repetitive loading (RL). The dorsiflexors …

Targeting the P-selectin/PSGL-1 Pathway: Discovery of Disease-Modifying Therapeutics for Disorders of Thromboinflammation

S Escopy, EL Chaikof - Blood Vessels, Thrombosis & …, 2024 - ashpublications.org
ABSTRACT P-selectin is a membrane glycoprotein and a member of the selectin family of
cell adhesion molecules. It is pre-stored in α-granules of platelets and Weibel-Palade bodies …

Normalization of brain death—induced injury to rat renal allografts by recombinant soluble p-selectin glycoprotein ligand

M Gasser, AM Waaga, JE Kist-Van Holthe… - Journal of the …, 2002 - journals.lww.com
Donor brain death has been considered a significant risk factor for both early and late organ
allograft dysfunction. This central injury not only evokes an upsurge of catecholamines with …

Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model

M Omasa, T Fukuse, S Toyokuni, Y Mizutani… - …, 2003 - journals.lww.com
Background. The role of glycine has not been investigated in lung ischemia-reperfusion
injury after cold preservation. Furthermore, the role of apoptosis after reperfusion following …

Mild hypothermia ameliorates lung ischemia reperfusion injury in an ex vivo rat lung model

T Shoji, M Omasa, T Nakamura, T Yoshimura… - European surgical …, 2005 - karger.com
Background: Ischemia reperfusion (IR) injury of the lung frequently occurs after
cardiopulmonary bypass, pulmonary thromboendarterectomy, lung transplantation, and …

Recent progress in the design of selectin inhibitors

SR Chhabra, ASA Rahim… - Mini Reviews in Medicinal …, 2003 - benthamdirect.com
The selectins are a family of cell-adhesion proteins that mediate the early stages of
leukocyte recruitment from the blood stream to sites of tissue damage through recognition of …

[图书][B] Discovery and Characterization of Glyco-Immune Checkpoints

BAH Smith - 2021 - search.proquest.com
Glycans are complex polysaccharides that decorate the surface of every cell in the human
body and have functions spanning many essential aspects of cell and organismal biology …

Untersuchung costimulatorischer Signalwege bei chronischer Transplantatabstoßung und Langzeit-Organakzeptanz nach allogener Nierentransplantation an einem …

MW Grimm - 2005 - opus.bibliothek.uni-wuerzburg.de
Zusammenfassend zeigen die Untersuchungsergebnisse, dass eine Kombination aus
niedrig dosiertem Sirolimus und CsA einen synergistischen immunsuppressiven Effekt nach …