Microfluidic characterization of single‐cell biophysical properties and the applications in cancer diagnosis

SS Li, CD Xue, YJ Li, XM Chen, Y Zhao… - Electrophoresis, 2024 - Wiley Online Library
Single‐cell biophysical properties play a crucial role in regulating cellular physiological
states and functions, demonstrating significant potential in the fields of life sciences and …

Glioma Single-Cell Biomechanical Analysis by Cyclic Conical Constricted Microfluidics

X Geng, ZA Zhou, Y Mi, C Wang, M Wang… - Analytical …, 2023 - ACS Publications
Determining the grade of glioma is a critical step in choosing patients' treatment plans in
clinical practices. The pathological diagnosis of patient's glioma samples requires extensive …

Electromechanical interactions between cell membrane and nuclear envelope: Beyond the standard Schwan's model of biological cells

E Sabri, C Brosseau - Bioelectrochemistry, 2024 - Elsevier
We investigate little-appreciated features of the hierarchical core–shell (CS) models of the
electrical, mechanical, and electromechanical interactions between the cell membrane (CM) …

MR elastography identifies regions of extracellular matrix reorganization associated with shorter survival in glioblastoma patients

SF Svensson, S Halldórsson… - Neuro-Oncology …, 2023 - academic.oup.com
Background Biomechanical tissue properties of glioblastoma tumors are heterogeneous, but
the molecular mechanisms involved and the biological implications are poorly understood …

Long-Term Stable and Multifeature Microfluidic Impedance Flow Cytometry Based on a Constricted Channel for Single-Cell Mechanical Phenotyping

SS Li, CD Xue, SY Hu, YJ Li, XM Chen… - Analytical …, 2024 - ACS Publications
The microfluidic impedance flow cytometer (m-IFC) using constricted microchannels is an
appealing choice for the high-throughput measurement of single-cell mechanical properties …

Artificial Neural Network-Aided Computational Approach for Mechanophenotyping of Biological Cells Using Atomic Force Microscopy

Y Kamble, A Raj, A Thakur - Journal of …, 2023 - asmedigitalcollection.asme.org
The artificial neural network (ANN) based models have shown the potential to provide
alternate data-driven solutions in disease diagnostics, cell sorting and overcoming AFM …

Liquid drops on compliant and non-compliant substrates: an ellipsoid-based fitting for approximating drop shape and volume

SA Haider, A Raj - Microfluidics and Nanofluidics, 2023 - Springer
We present a novel method of 3-dimensional surface fitting of a droplet using ellipsoids such
that the droplet is a combination of segments of two to four distinct ellipsoids. Further, this …

Atomic force microscope nanoindentation analysis of diffuse astrocytic tumor elasticity: relation with tumor histopathology

A Tsitlakidis, AS Tsingotjidou, A Kritis, A Cheva… - Cancers, 2021 - mdpi.com
Simple Summary Biomechanics has emerged as a key player in diffuse glioma progression
and invasion, as the glioma cells interact both chemically and mechanically with the …

Exploring fluid flow in microchannels with branching and variable constrictions

R Kumar, AB Ghosh, B Borah, R Lakkaraju… - Microfluidics and …, 2024 - Springer
We employ a three-dimensional numerical model to analyze the dynamics of single-phase
flow in a parallel branched microchannel with varying geometric dimensions of constrictions …

Stiffness estimation and classification of biological cells using constriction microchannel: poroelastic model and machine learning

SA Haider, G Kumar, T Goyal, A Raj - Microfluidics and Nanofluidics, 2024 - Springer
Mathematical and computational models linking cell mechanical properties with deformation
are crucial for understanding cellular behavior. While various techniques measure the …