Hypertension, which is characterized by multiple alterations in the structure and function of
the cell membrane, is often associated with important metabolic abnormalities including …

In most cell types, including resting skeletal muscle fibers, internal pH (pHi) is kept constant
at a relatively alkaline level. The high pHi is obtained in spite of a chronic acid load resulting …

Human red blood cells (RBCs) that are deficient in an integral membrane-associated protein
(“stomatin “) of apparent molecular mass 31 Kd show a catastrophic increase in passive …

We show how quantitative information about proton handling in human skeletal muscle in
exercise and recovery can be obtained by 31P MRS and illustrate this with data from …

Previous studies have shown that ATP and UTP are able to stimulate phospholipase C
(PLC) and proliferation in cultured aortic smooth muscle cells. Here we set out to …

Increased activity of the cellular Na+-H+ exchangers (NHEs), especially isoform 1 (NHE-1),
is a recognized intermediate phenotype of hypertension. NHE activity has been …

We used 31P magnetic resonance spectroscopy to compare the response of rat skeletal
muscle to three kinds of proton load. During exercise (tetanic sciatic nerve stimulation) …

Demonstrating that the magnitude and pattern of cardiovascular response to stress varies
markedly between individuals, this work discusses the mechanisms by which the …

Increased activity of the Na+-H+ exchanger (NHE-1 isoform) has been observed in cells and
tissues from hypertensive humans and animals, including the spontaneously hypertensive …

Previous studies have demonstrated an elevated Na+-H+ exchanger activity in various cell
types from patients with essential hypertension. The phenotype of an increased maximal …