Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
The diseased brain hosts a heterogeneous population of myeloid cells, including
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …
parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne …
The pathophysiological role of microglia in dynamic surveillance, phagocytosis and structural remodeling of the developing CNS
In vertebrates, during an early wave of hematopoiesis in the yolk sac between embryonic
day E7. 0 and E9. 0, cells of mesodermal leaflet addressed to macrophage lineage enter in …
day E7. 0 and E9. 0, cells of mesodermal leaflet addressed to macrophage lineage enter in …
Immune activation in brain aging and neurodegeneration: too much or too little?
KM Lucin, T Wyss-Coray - Neuron, 2009 - cell.com
Until recently, the brain was studied almost exclusively by neuroscientists and the immune
system by immunologists, fuelling the notion that these systems represented two isolated …
system by immunologists, fuelling the notion that these systems represented two isolated …
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
A Mildner, H Schmidt, M Nitsche, D Merkler… - Nature …, 2007 - nature.com
Microglia are crucially important myeloid cells in the CNS and constitute the first
immunological barrier against pathogens and environmental insults. The factors controlling …
immunological barrier against pathogens and environmental insults. The factors controlling …
Inflammation as a causative factor in the aetiology of Parkinson's disease
PS Whitton - British journal of pharmacology, 2007 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting mainly the
elderly, although a small proportion of PD patients develop the illness at a much younger …
elderly, although a small proportion of PD patients develop the illness at a much younger …
Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease
A Mildner, B Schlevogt, K Kierdorf… - Journal of …, 2011 - Soc Neuroscience
Mononuclear phagocytes are important modulators of Alzheimer9s disease (AD), but the
specific functions of resident microglia, bone marrow-derived mononuclear cells, and …
specific functions of resident microglia, bone marrow-derived mononuclear cells, and …
The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders
PJ Urrutia, NP Mena, MT Núñez - Frontiers in pharmacology, 2014 - frontiersin.org
A growing set of observations points to mitochondrial dysfunction, iron accumulation,
oxidative damage and chronic inflammation as common pathognomonic signs of a number …
oxidative damage and chronic inflammation as common pathognomonic signs of a number …
Microglia in the developing brain: a potential target with lifetime effects
GJ Harry, AD Kraft - Neurotoxicology, 2012 - Elsevier
Microglia are a heterogenous group of monocyte-derived cells serving multiple roles within
the brain, many of which are associated with immune and macrophage like properties …
the brain, many of which are associated with immune and macrophage like properties …
Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms
Microglia are unique cells within the central nervous system because of their biophysical
independence. As a result of this unusual property the cells must undergo significant …
independence. As a result of this unusual property the cells must undergo significant …
Brain metastasis: Unique challenges and open opportunities
The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical
reality, carrying an estimated survival time of less than one year in spite of recent therapeutic …
reality, carrying an estimated survival time of less than one year in spite of recent therapeutic …