Current advances and development strategies of orally bioavailable PROTACs
S Zeng, Y Ye, H Xia, J Min, J Xu, Z Wang, Y Pan… - European Journal of …, 2023 - Elsevier
Proteolysis-targeting chimeras (PROTACs) have been an area of intensive research with the
potential to extend drug space not target to traditional molecules. In the last half decade, we …
potential to extend drug space not target to traditional molecules. In the last half decade, we …
Unveiling Nature's potential: promising natural compounds in Parkinson's disease management
CK Bhusal, DE Uti, D Mukherjee, T Alqahtani… - Parkinsonism & Related …, 2023 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta …
progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta …
Synergizing proteolysis-targeting chimeras and nanoscale exosome-based delivery mechanisms for HIV and antiviral therapeutics
N Mukerjee, S Maitra, A Ghosh… - ACS Applied Nano …, 2024 - ACS Publications
The global fight against Human Immunodeficiency Virus (HIV) and related viral infections
stands at a pivotal juncture, demanding groundbreaking therapeutic strategies. Facing the …
stands at a pivotal juncture, demanding groundbreaking therapeutic strategies. Facing the …
Revolutionizing viral disease treatment: PROTACs therapy could be the ultimate weapon of the future.
N Mukerjee, A Ghosh - Journal of Medical Virology, 2023 - search.ebscohost.com
Lastly, the emergence of viral resistance is a concern when developing antiviral therapies.[7]
Continuous exposure to PROTACs could lead to the selection of viral mutants with altered …
Continuous exposure to PROTACs could lead to the selection of viral mutants with altered …
Revolutionizing Human papillomavirus (HPV)‐related cancer therapies: Unveiling the promise of Proteolysis Targeting Chimeras (PROTACs) and Proteolysis …
Personalized cancer immunotherapies, combined with nanotechnology (nano‐vaccines),
are revolutionizing cancer treatment strategies, explicitly targeting Human papilloma virus …
are revolutionizing cancer treatment strategies, explicitly targeting Human papilloma virus …
Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety
R Zhang, S Xie, J Ran, T Li - Journal of Cellular Physiology, 2024 - Wiley Online Library
Abstract Proteolysis Targeting Chimeras (PROTACs) represent a significant advancement in
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable …
Revolutionizing Cancer Treatment: Unleashing the Power of Viral Vaccines, Monoclonal Antibodies, and Proteolysis-Targeting Chimeras in the New Era of …
In the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated
strategies that encompass both traditional cancer vaccines and emerging viral vaccines …
strategies that encompass both traditional cancer vaccines and emerging viral vaccines …
Neuroendocrine and cellular mechanisms in stress resilience: From hormonal influence in the CNS to mitochondrial dysfunction and oxidative stress
A Bhattacharya, M Chakraborty… - Journal of Cellular …, 2024 - Wiley Online Library
Recent advancements in neuroendocrinology challenge the long‐held belief that hormonal
effects are confined to perivascular tissues and do not extend to the central nervous system …
effects are confined to perivascular tissues and do not extend to the central nervous system …
Interplay of precision therapeutics and MD study: Calocybe indica's potentials against cervical cancer and its interaction with VEGF via octadecanoic acid
The evolving landscape of personalized medicine necessitates a shift from traditional
therapeutic interventions towards precision‐driven approaches. Embracing this paradigm …
therapeutic interventions towards precision‐driven approaches. Embracing this paradigm …
[HTML][HTML] Exploring the Frontier of Biopolymer-Assisted Drug Delivery: Advancements, Clinical Applications, and Future Perspectives in Cancer Nanomedicine
HM Alharbi - Drug Design, Development and Therapy, 2024 - ncbi.nlm.nih.gov
The burgeoning global mortality rates attributed to cancer have precipitated a critical
reassessment of conventional therapeutic modalities, most notably chemotherapy, due to …
reassessment of conventional therapeutic modalities, most notably chemotherapy, due to …