Although RAS was formerly considered undruggable, various agents that inhibit RAS or
specific RAS oncoproteins have now been developed. Indeed, the importance of directly …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Triple negative breast cancer (TNBC) cells have a high demand for oxygen and glucose to
fuel their growth and spread, shaping the tumor microenvironment (TME) that can lead to a …

Metastases, which are the leading cause of death in patients with cancer, have metabolic
vulnerabilities. Alterations in metabolism fuel the energy and biosynthetic needs of …

The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …

Cancer cells have adapted to rapid tumor growth and evade immune attack by
reprogramming their metabolic pathways. Glutamine is an important nitrogen resource for …

Heightened lactate production in cancer cells has been linked to various cellular
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …

Metabolic reprogramming is a hallmark of cancer, driving the development of therapies
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …

Asparagine is a non-essential amino acid crucial for protein biosynthesis and function, and
therefore cell maintenance and growth. Furthermore, this amino acid has an important role …

A promising approach to treat solid tumors involves disrupting their reliance on glutamine, a
key component for various metabolic processes. Traditional attempts using glutamine …