Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

The RNA‐binding protein Quaking (QKI) has emerged as a potent regulator of cellular
differentiation in developmental and pathological processes. The QKI gene is itself …

Advances in single-cell technologies allow scrutinizing of heterogeneous cell states,
however, detecting cell-state transitions from snap-shot single-cell transcriptome data …

The RNA velocity provides a new avenue to study the stemness and lineage of cells in the
development in scRNA-seq data analysis. Some promising extensions of it are proposed …

In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased
by the overexpression of a few genes, resulting in regaining pluripotency, the potential for …

Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is
determined by intricate and nonlinear interactions among molecules, making mathematical …

Colorectal cancer has proven to be difficult to treat as it is the second leading cause of
cancer death for both men and women worldwide. Recent work has shown the importance …

Living systems adapt to various environmental conditions by changing their internal states
through processes such as gene expression and epigenetic modification. In this paper, we …

The emergence of RNA velocity has enriched our understanding of the dynamic
transcriptional landscape within individual cells. In light of this breakthrough, we embarked …