Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for
assessing mitochondrial function, particularly in the context of cell fate determination in …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk
for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying …

Several lines of evidence indicate that mitochondrial reactive oxygen species (ROS)
generation is the major source of oxidative stress in the cell. It has been shown that ROS …

In recent years we have witnessed a major interest in the study of the role of mitochondria,
not only as ATP producers through oxidative phosphorylation but also as regulators of …

Transgenic mice overexpressing the P301L mutant human tau protein exhibit an
accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The …

Programmed cell death is a major component of both normal development and disease. The
roles of cell death during either embryogenesis or pathogenesis, the signals that modulate …

Melatonin, the secretory product of the pineal gland, is known to be neuroprotective in
cerebral ischemia, which is so far mostly attributed to its antioxidant properties. Here we …

Mitochondria play a critical role in apoptosis induction in response to myriad stimuli. These
organelles release proteins into the cytosol which trigger caspase activation or perform other …

Primary dissociated neuronal cultures have been intensively exploited for the past 15 years
as model systems to investigate excitotoxic neuronal degeneration. Even this simplified …