[HTML][HTML] Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

Targeting neuroinflammation in Alzheimer's disease

MR Bronzuoli, A Iacomino, L Steardo… - Journal of inflammation …, 2016 - Taylor & Francis
Almost 47 million people suffer from dementia worldwide, with an estimated new case
diagnosed every 3.2 seconds. Alzheimer's disease (AD) accounts for approximately 60 …

Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

GK Sheridan, KJ Murphy - Open biology, 2013 - royalsocietypublishing.org
An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

[HTML][HTML] Old maids: aging and its impact on microglia function

EC Koellhoffer, LD McCullough, RM Ritzel - International journal of …, 2017 - mdpi.com
Microglia are highly active and vigilant housekeepers of the central nervous system that
function to promote neuronal growth and activity. With advanced age, however …

Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer's disease: Rational insights for the therapeutic approaches

MH Ahmad, M Fatima, AC Mondal - Journal of Clinical Neuroscience, 2019 - Elsevier
Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder is characterized by the formation of extracellular amyloid plaques and intracellular …

An overview of the cannabinoid type 2 receptor system and its therapeutic potential

B Bie, J Wu, JF Foss, M Naguib - Current Opinion in …, 2018 - journals.lww.com
An overview of the cannabinoid type 2 receptor system and it... : Current Opinion in
Anesthesiology An overview of the cannabinoid type 2 receptor system and its therapeutic …

Alzheimer s disease and oxidative stress: a review

M Pohanka - Current medicinal chemistry, 2014 - ingentaconnect.com
Alzheimer´ s disease (AD) is a neurodegenerative disorder with no known cure and rapid
rise in incidence. The predominant cognitive impairment is currently treated using cognitive …

[HTML][HTML] Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

C Limatola, RM Ransohoff - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Since the initial cloning of fractalkine/CX3CL1, it was proposed that the only known member
of the CX3C or δ subfamily of chemotactic cytokines could play some significant role in the …

[HTML][HTML] Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors

C Liu, G Cui, M Zhu, X Kang, H Guo - International journal of …, 2014 - ncbi.nlm.nih.gov
Chemokines secreted by astrocytes play multiple roles in the pathology of Alzheimer's
disease, a chronic inflammation disorder of central nervous system. The level of chemokines …

[HTML][HTML] Role of Chemokines in the Development and Progression of Alzheimer's Disease

J Wojcieszak, K Kuczyńska, JB Zawilska - Journal of Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a progressive neurogenerative disorder manifested by gradual
memory loss and cognitive decline due to profound damage of cholinergic neurons. The …