Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and
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Recent data indicate that'classical'neurotransmitters can also act as co-transmitters. This
notion has been strengthened by the demonstration that three vesicular glutamate …

The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by
negatively valenced events. Its hyperactivity is associated with depression. Although …

Neurons in the developing auditory system exhibit spontaneous bursts of activity before
hearing onset. How this intrinsically generated activity influences development remains …

Neurotransmitter identity is a defining feature of all neurons because it constrains the type of
information they convey, but many neurons release multiple transmitters. Although the …

Patterned spontaneous activity is a hallmark of developing sensory systems. In the auditory
system, rhythmic bursts of spontaneous activity are generated in cochlear hair cells and …

Highlights•Co-release and co-transmission are distinct, separate modes of release.•There
are multiple classes of dual-transmitter neurons.•The consequence of co-release extends …

Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …

For decades, it has been thought that glutamate and GABA are released by distinct neurons.
However, some mouse neurons innervating the lateral habenula (LHb) co-release …

Despite its ubiquity and significance, behavioral habituation is poorly understood in terms of
the underlying neural circuit mechanisms. Here, we present evidence that habituation arises …