Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Protein arginine methyltransferases and cancer

Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis

L Wang, Z Zhao, MB Meyer, S Saha, M Yu, A Guo… - Cancer cell, 2014 - cell.com
Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various
cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the …

The interplay between exercise metabolism, epigenetics, and skeletal muscle remodeling

RA Seaborne, AP Sharples - Exercise and Sport Sciences …, 2020 - journals.lww.com
• Exercise changes the abundance of a number of important metabolites and substrates to
keep our muscles contracting.• These metabolites may serve as substrates to enable …

Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment

RC Kiss, F Xia, S Acklin - International journal of molecular sciences, 2021 - mdpi.com
Platinum-based chemotherapies, such as cisplatin, play a large role in cancer treatment.
The development of resistance and treatment toxicity creates substantial barriers to disease …

BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity

EJ Kim, P Liu, S Zhang, K Donahue… - Nucleic acids …, 2021 - academic.oup.com
Subunits of the chromatin remodeler SWI/SNF are the most frequently disrupted genes in
cancer. However, how post-translational modifications (PTM) of SWI/SNF subunits elicit …

[HTML][HTML] EZH2 inhibition sensitizes CARM1-high, homologous recombination proficient ovarian cancers to PARP inhibition

S Karakashev, T Fukumoto, B Zhao, J Lin, S Wu… - Cancer Cell, 2020 - cell.com
In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a
critical role in the choice between homologous recombination (HR) and non-homologous …

Readers of histone methylarginine marks

S Gayatri, MT Bedford - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation …

Accumulation of histone variant H3. 3 with age is associated with profound changes in the histone methylation landscape

A Tvardovskiy, V Schwämmle, SJ Kempf… - Nucleic acids …, 2017 - academic.oup.com
Deposition of replication-independent histone variant H3. 3 into chromatin is essential for
many biological processes, including development and reproduction. Unlike replication …

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

F Dong, Q Li, C Yang, D Huo, X Wang, C Ai… - Nature …, 2018 - nature.com
Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus,
identification of epigenetic modifiers essential for oncogenic transcriptional programs is a …