Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

An urgent call to raise the bar in oncology

JJB Schnog, MJ Samson, ROB Gans… - British journal of cancer, 2021 - nature.com
Important breakthroughs in medical treatments have improved outcomes for patients
suffering from several types of cancer. However, many oncological treatments approved by …

An arm and a leg: the rising cost of cancer drugs and impact on access.

NB Leighl, S Nirmalakumar, DA Ezeife… - American Society of …, 2021 - europepmc.org
Increasing cancer drug prices present global challenges to treatment access and cancer
outcomes. Substantial variability exists in drug pricing across countries. In countries without …

Association between FDA and EMA expedited approval programs and therapeutic value of new medicines: retrospective cohort study

TJ Hwang, JS Ross, KN Vokinger, AS Kesselheim - bmj, 2020 - bmj.com
Objective To characterize the therapeutic value of new drugs approved by the US Food and
Drug Administration (FDA) and European Medicines Agency (EMA) and the association …

Analysis of launch and postapproval cancer drug pricing, clinical benefit, and policy implications in the US and Europe

KN Vokinger, TJ Hwang, P Daniore, CWC Lee… - JAMA …, 2021 - jamanetwork.com
Importance The high cost of cancer medicines is a public health challenge. Policy makers in
the US and Europe are debating reforms to drug pricing that would cover both the prices of …

Changes in survival in de novo metastatic cancer in an era of new medicines

M Luyendijk, O Visser, HM Blommestein… - JNCI: Journal of the …, 2023 - academic.oup.com
Background Over the past decades, the therapeutic landscape has markedly changed for
patients with metastatic solid cancer, yet few studies have evaluated its effect on population …

AI-driven synthetic biology for non-small cell lung cancer drug effectiveness-cost analysis in intelligent assisted medical systems

L Chang, J Wu, N Moustafa… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
According to statistics, in the 185 countries' 36 types of cancer, the morbidity and mortality of
lung cancer take the first place, and non-small cell lung cancer (NSCLC) accounts for 85 …

An appraisal of FDA approvals for adult solid tumours in 2017–2021: has the eagle landed?

NI Cherny - Nature Reviews Clinical Oncology, 2022 - nature.com
In 2016, the then US President Barack Obama announced the Cancer Moonshot with a view
to making 10 years' worth of progress in cancer prevention, diagnosis and treatment in only …

Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study

KN Vokinger, CEG Glaus, AS Kesselheim… - bmj, 2023 - bmj.com
Objective To analyze the therapeutic value of supplemental indications compared with first
indications for drugs approved in the US and Europe. Design Retrospective cohort study …

Association of research and development investments with treatment costs for new drugs approved from 2009 to 2018

OJ Wouters, LA Berenbrok, M He, Y Li… - JAMA network …, 2022 - jamanetwork.com
Importance Drug companies frequently claim that high prices are needed to recoup
spending on research and development. If high research and development costs justified …