C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

Vascular smooth muscle tone is controlled by a balance between the cellular signaling
pathways that mediate the generation of force (vasoconstriction) and release of force …

Natriuretic peptides (NPs), including atrial, brain and C‐type natriuretic peptides (ANP, BNP
and CNP), bind two classes of cell surface receptors: the guanylyl cyclase‐linked A and B …

Natriuretic peptides play a fundamental role in cardiovascular homeostasis by modulation of
fluid and electrolyte balance and vascular tone. C-type natriuretic peptide (CNP) represents …

B-type natriuretic peptide (BNP) is a member of the natriuretic peptide family, a group of
widely distributed, but evolutionarily conserved, polypeptide mediators that exert myriad …

Natriuretic peptides play a critical role in coordination of fluid/electrolyte balance and
vascular tone. The renal effects of circulating atrial natriuretic peptide (ANP) and brain …

Aims Under hypoxic conditions, nitrite (NO 2−) can be reduced to nitric oxide (NO) eliciting
vasorelaxation. However, nitrite also exerts vasorelaxant effects of potential therapeutic …

Cyclic GMP-dependent and-independent mechanisms their endogenous receptors and
highlight recent work that has revealed important interactions between the cyclic GMP …

Objective: C-type natriuretic peptide (CNP) has recently been suggested to represent an
endothelium-derived hyperpolarising factor (EDHF) in the mammalian resistance …

Cerebral blood flow (CBF) is highly regulated by changes in arterial Pco2 and arterial Po2.
Evidence from animal studies indicates that various vasoactive factors, including release of …