Cannabinoid therapeutics in chronic neuropathic pain: from animal research to human treatment
RMP Campos, AFL Aguiar, Y Paes-Colli… - Frontiers in …, 2021 - frontiersin.org
Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …
is frequently caused by damage in the nervous system, followed by persistence over a long …
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review
M Bryk, K Starowicz - Pharmacological Reports, 2021 - Springer
Over the last several decades, the percentage of patients suffering from different forms of
arthritis has increased due to the ageing population and the increasing risk of civilization …
arthritis has increased due to the ageing population and the increasing risk of civilization …
The importance of TRPV1-sensitisation factors for the development of neuropathic pain
N Malek, A Pajak, N Kolosowska, M Kucharczyk… - Molecular and Cellular …, 2015 - Elsevier
Transient receptor potential vanilloid type 1 (TRPV1), classically associated with
transduction of high-temperature and low-pH pain, underlies pain hypersensitivity in …
transduction of high-temperature and low-pH pain, underlies pain hypersensitivity in …
Gut microbiome and plasma metabolome signatures in middle-aged mice with cognitive dysfunction induced by chronic neuropathic pain
D Hua, S Li, S Li, X Wang, Y Wang, Z Xie… - Frontiers in Molecular …, 2022 - frontiersin.org
Patients with chronic neuropathic pain (CNP) often complain about their terrible memory,
especially the speed of information processing. Accumulating evidence suggests a possible …
especially the speed of information processing. Accumulating evidence suggests a possible …
Alterations in anandamide synthesis and degradation during osteoarthritis progression in an animal model
M Bryk, J Chwastek, M Kostrzewa, J Mlost… - International Journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and
chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid …
chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid …
The FKBP51 inhibitor SAFit2 restores the pain-relieving C16 dihydroceramide after nerve injury
S Wedel, L Hahnefeld, MW Alnouri… - International Journal of …, 2022 - mdpi.com
Neuropathic pain is a pathological pain state with a broad symptom scope that affects
patients after nerve injuries, but it can also arise after infections or exposure to toxic …
patients after nerve injuries, but it can also arise after infections or exposure to toxic …
Antihyperalgesic activities of endocannabinoids in a mouse model of antiretroviral-induced neuropathic pain
N Munawar, MA Oriowo, W Masocha - Frontiers in pharmacology, 2017 - frontiersin.org
Background: Nucleoside reverse transcriptase inhibitors (NRTIs) are the cornerstone of the
antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency …
antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency …
The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain
N Malek, M Kostrzewa, W Makuch, A Pajak… - Pharmacological …, 2016 - Elsevier
There is considerable evidence to support the role of anandamide (AEA), an endogenous
ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects …
ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects …
Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat …
A Pajak, M Kostrzewa, N Malek… - Journal of pain …, 2017 - Taylor & Francis
Matrix metalloproteinases (MMPs) are considered important in articular cartilage breakdown
during osteoarthritis (OA). Similarly, the endocannabinoid system (ECS) is implicated in joint …
during osteoarthritis (OA). Similarly, the endocannabinoid system (ECS) is implicated in joint …
Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy …
MF Mahmoud, S Rezq, AE Alsemeh… - Frontiers in …, 2021 - frontiersin.org
Sciatic nerve injury is often associated with neuropathic pain and neuroinflammation in the
central and peripheral nervous systems. In our previous work, Potamogeton perfoliatus L …
central and peripheral nervous systems. In our previous work, Potamogeton perfoliatus L …