Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations
The acquisition of fear associative memory requires brain processes of coordinated neural
activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem …
activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem …
Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …
behaviors such as cognition, movement, and reward, making them ideally situated as …
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
[HTML][HTML] From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer's disease
AJH Brown, SJ Bradley, FH Marshall, GA Brown… - Cell, 2021 - cell.com
Current therapies for Alzheimer's disease seek to correct for defective cholinergic
transmission by preventing the breakdown of acetylcholine through inhibition of …
transmission by preventing the breakdown of acetylcholine through inhibition of …
Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited
understanding of the molecular and experience-dependent mechanisms that regulate …
understanding of the molecular and experience-dependent mechanisms that regulate …
Targeting muscarinic receptors to treat schizophrenia
Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of
symptoms that can have profound impacts on the lives of patients. Currently available …
symptoms that can have profound impacts on the lives of patients. Currently available …
Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders
The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …
executive and emotional functions. Neurophysiological studies have begun to unveil the …
Prefrontal interneurons: populations, pathways, and plasticity supporting typical and disordered cognition in rodent models
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
Muscarinic M1 and M4 receptor agonists for schizophrenia: promising candidates for the therapeutic arsenal
B Dean - Expert Opinion on Investigational Drugs, 2023 - Taylor & Francis
Introduction Successful phase 3 trials of KarXT in people with schizophrenia herald a new
era of treating the disorder with drugs that do not target the dopamine D2 receptor. The …
era of treating the disorder with drugs that do not target the dopamine D2 receptor. The …
mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent
findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest …
findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest …