Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

A central goal in the development of genome engineering technology is to reduce the time
and labor required to produce custom genome modifications. Here we describe a new …

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue
architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the …

Microtubules are born and reborn continuously, even during quiescence. These polymers
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …

Fast growth of microtubules is essential for rapid assembly of the microtubule cytoskeleton
during cell proliferation and differentiation. XMAP215 belongs to a conserved family of …

Chromosome segregation in mammalian oocytes is driven by a microtubule spindle lacking
centrosomes. Here, we analyze centrosome-independent spindle assembly by quantitative …

The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer
amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although …

Asymmetric cell division is fundamental for generating diversity in multicellular organisms.
The mechanisms that govern asymmetric cell division are increasingly well understood …

Cell biological studies have shown that protofilament number, a fundamental feature of
microtubules, can correlate with the expression of different tubulin isotypes. However, it is …