[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Subpopulations of extracellular vesicles and their therapeutic potential

C Lässer, SC Jang, J Lötvall - Molecular aspects of medicine, 2018 - Elsevier
Extracellular vesicles (EVs), such as exosomes and microvesicles, have over the last 10–15
years been recognized to convey key messages in the molecular communication between …

Exosome composition and seminal plasma proteome: A promising source of biomarkers of male infertility

L Candenas, R Chianese - International journal of molecular sciences, 2020 - mdpi.com
Infertility has become a global health issue, with approximately 50% of infertility cases
generated by disorders in male reproduction. Spermatozoa are conveyed towards female …

[HTML][HTML] The female response to seminal fluid

JE Schjenken, SA Robertson - Physiological reviews, 2020 - journals.physiology.org
Seminal fluid is often assumed to have just one function in mammalian reproduction,
delivering sperm to fertilize oocytes. But seminal fluid also transmits signaling agents that …

Semen proteomics and male infertility

M Jodar, A Soler-Ventura, R Oliva… - Journal of …, 2017 - Elsevier
Semen is a complex body fluid containing an admixture of spermatozoa suspended in
secretions from the testes and epididymis which are mixed at the time of ejaculation with …

Exosomes and cancer: from molecular mechanisms to clinical applications

A Jafari, A Babajani, M Abdollahpour-Alitappeh… - Medical Oncology, 2021 - Springer
Exosomes are extracellular nanovesicles secreted from almost all types of normal and
cancer cells. Collective evidence suggests that exosomes participate in cell–cell …

Comprehensive proteomics analysis of exosomes derived from human seminal plasma

C Yang, W Guo, W Zhang, J Bian, J Yang, Q Zhou… - …, 2017 - Wiley Online Library
Exosomes are membranous nanovesicles of endocytic origin that carry and transfer
regulatory bioactive molecules and mediate intercellular communication between cells and …

[HTML][HTML] Extracellular vesicles and energy metabolism

KG Ronquist - Clinica chimica acta, 2019 - Elsevier
Glycolytic enzymes are among the most frequently identified proteins in proteomics of
exosomes/extracellular vesicles. This review brings up the possibility that exosomes …

[HTML][HTML] Seminal plasma of men with severe asthenozoospermia contain exosomes that affect spermatozoa motility and capacitation

V Murdica, E Giacomini, A Alteri, A Bartolacci… - Fertility and sterility, 2019 - Elsevier
Objective To characterize in depth and investigate the role of exosomes present in seminal
plasma in affecting parameters underlying sperm activity. Design In vitro experimental study …

Roles of male reproductive tract extracellular vesicles in reproduction

CT Tamessar, NA Trigg, B Nixon… - American Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are secreted cell‐derived membrane structures present in all
organisms across animal, bacterial, and plant phyla. These vesicles play important roles in …