[PDF][PDF] Hepatic stellate cells and liver fibrosis

JE Puche, Y Saiman, SL Friedman - Compr Physiol, 2013 - academia.edu
Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

[HTML][HTML] Matrix metalloproteinases in liver injury, repair and fibrosis

S Duarte, J Baber, T Fujii, AJ Coito - Matrix Biology, 2015 - Elsevier
The liver is a large highly vascularized organ with a central function in metabolic
homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to …

[HTML][HTML] Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

D Lindén, A Ahnmark, P Pingitore, E Ciociola… - Molecular …, 2019 - Elsevier
Objective Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of
advanced chronic liver disease. The progression of NAFLD, including nonalcoholic …

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

SL Friedman - Physiological reviews, 2008 - journals.physiology.org
The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Cooperation of liver cells in health and disease: with 18 tables

Z Kmiec - 2001 - books.google.com
It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

MS Roberts, BM Magnusson, FJ Burczynski… - Clinical …, 2002 - Springer
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute,
sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often …

Pathogenesis of liver fibrosis: role of oxidative stress

G Poli - Molecular aspects of medicine, 2000 - Elsevier
In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

Hepatic fibrosis—overview

SL Friedman - Toxicology, 2008 - Elsevier
The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed
tremendous progress in the past two decades. Clarification of the cellular sources of scar …

Matrix metalloproteinase inhibitors

SM Wojtowicz-Praga, RB Dickson… - Investigational new drugs, 1997 - Springer
The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and
membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all of the …

Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy

D Li, S Friedman - Journal of gastroenterology and hepatology, 1999 - Wiley Online Library
Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …