Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

Ultraviolet light is strongly absorbed by DNA, producing excited electronic states that
sometimes initiate damaging photochemical reactions. Fully mapping the reactive and …

Genome integrity is continuously challenged by the DNA damage that arises during normal
cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme …

Recurrent mutations are frequently associated with transcription factor (TF) binding sites
(TFBS) in melanoma, but the mechanism driving mutagenesis at TFBS is unclear. Here, we …

Biochemical reactions are subject to the particular environmental conditions of planet earth,
including solar irradiation. How DNA responds to radiation is relevant to human health …

Ultraviolet (UV) radiation is a leading external hazard to the integrity of DNA. Exposure to UV
radiation triggers a cascade of chemical reactions, and many molecular products …

The study addresses interconnected issues related to two major types of cycloadditions
between adjacent thymines in DNA leading to cyclobutane dimers (T<> Ts) and (6-4) …

Somatic mutations in DNA‐binding sites for CCCTC‐binding factor (CTCF) are significantly
elevated in many cancers. Prior analysis has suggested that elevated mutation rates at …

The formation of cyclobutane thymine dimers is one of the most important DNA carcinogenic
photolesions induced by ultraviolet irradiation. The long debated question whether thymine …

Biologically derived metal-organic frameworks (bio-MOFs) are of great importance as they
can be used as models for bio-mimicking and in catalysis, allowing us to gain insights into …