Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life,
morbidity and mortality. Despite the new available criteria, its early diagnosis remains …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Muscle protein wasting in cancer cachexia is a critical problem. The underlying mechanisms
are still unclear, although the ubiquitin-proteasome system has been involved in the …

Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …

Background Pharmacological corticosteroid therapy is the standard of care in Duchenne
Muscular Dystrophy (DMD) that aims to control symptoms and slow disease progression …

Purpose Corticosteroids are frequently used in cancer pain management despite limited
evidence. This study compares the analgesic efficacy of corticosteroid therapy with placebo …

In the next decade, Chronic Obstructive Pulmonary Disease (COPD) will be a major leading
cause of death worldwide. Impaired muscle function and mass are common systemic …