Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

Polo-like kinases (Plks) are potent regulators of M phase that are conserved from yeasts to
humans. Their roles in mitotic entry, spindle pole functions and cytokinesis are broadly …

Background Image-based screens can produce hundreds of measured features for each of
hundreds of millions of individual cells in a single experiment. Results Here, we describe …

The mitosis-to-interphase transition involves dramatic cellular reorganization from a state
that supports chromosome segregation to a state that complies with all functions of an …

Entry into mitosis depends on the activity of cyclin‐dependent kinases (CDKs). Conversely,
exit from mitosis occurs when mitotic cyclins are degraded, thereby extinguishing CDK …

Loss of cell division cycle 2 (Cdc2, also known as Cdk1) activity after cyclin B degradation is
necessary, but not sufficient, for mitotic exit. Proteins phosphorylated by Cdc2 and …

Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and
regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man: PP1 …

Many protein kinases are activated by a conserved regulatory step involving T-loop
phosphorylation. Although there is considerable focus on kinase activator proteins, the …

The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

Abstract Tap42/α4, a regulatory subunit of protein phosphatase 2A, is a downstream effector
of the target of rapamycin (TOR) protein kinase, which regulates cell growth in coordination …