Mechanotransduction in development
E Farge - Current topics in developmental biology, 2011 - Elsevier
Biochemical patterning and morphogenetic movements coordinate the design of embryonic
development. The molecular processes that pattern and closely control morphogenetic …
development. The molecular processes that pattern and closely control morphogenetic …
Cell confinement: putting the squeeze on the nucleus
The nucleus has long been considered as a passive compartment containing the genetic
information. However, recent attention to its structure, mechanical properties and physical …
information. However, recent attention to its structure, mechanical properties and physical …
Loops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling
Layers of genome organization are becoming increasingly better characterized, but less is
known about how these structures respond to perturbation or shape changes. Low-salt …
known about how these structures respond to perturbation or shape changes. Low-salt …
Correlated spatio-temporal fluctuations in chromatin compaction states characterize stem cells
Stem cells integrate signals from the microenvironment to generate lineage-specific gene
expression programs upon differentiation. Undifferentiated cell nuclei are easily deformable …
expression programs upon differentiation. Undifferentiated cell nuclei are easily deformable …
Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections
KM Imbalzano, N Cohet, Q Wu, JM Underwood… - PloS one, 2013 - journals.plos.org
Changes in nuclear morphology occur during normal development and have been observed
during the progression of several diseases. The shape of a nucleus is governed by the …
during the progression of several diseases. The shape of a nucleus is governed by the …
Volume transitions of isolated cell nuclei induced by rapid temperature increase
Understanding the physical mechanisms governing nuclear mechanics is important as it can
impact gene expression and development. However, how cell nuclei respond to external …
impact gene expression and development. However, how cell nuclei respond to external …
Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation
MM Drozdz, DJ Vaux - Nucleus, 2017 - Taylor & Francis
The mammalian nuclear envelope (NE) can develop complex dynamic membrane-bounded
invaginations in response to both physiological and pathological stimuli. Since the formation …
invaginations in response to both physiological and pathological stimuli. Since the formation …
Condensins Exert Force on Chromatin-Nuclear Envelope Tethers to Mediate Nucleoplasmic Reticulum Formation in Drosophila melanogaster
Although the nuclear envelope is known primarily for its role as a boundary between the
nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular …
nucleus and cytoplasm in eukaryotes, it plays a vital and dynamic role in many cellular …
Nuclear organization during hepatogenesis in zebrafish requires Uhrf1
Acquisition of cellular fate during development is initiated and maintained by well-
coordinated patterns of gene expression that are dictated by the epigenetic landscape and …
coordinated patterns of gene expression that are dictated by the epigenetic landscape and …
A 3D-induced pluripotent stem cell-derived human neural culture model to study certain molecular and biochemical aspects of Alzheimer's disease
P Prasannan, E Siney, S Chatterjee, D Johnston… - In vitro models, 2022 - Springer
Purpose Alzheimer's disease (AD) early pathology needs better understanding and models.
Here, we describe a human induced pluripotent stem cells (iPSCs)-derived 3D neural …
Here, we describe a human induced pluripotent stem cells (iPSCs)-derived 3D neural …