Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets
G protein Gβγ subunits are key mediators of G protein-coupled receptor (GPCR) signaling
under physiological and pathological conditions; their inhibitors have been tested for the …
under physiological and pathological conditions; their inhibitors have been tested for the …
[HTML][HTML] Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases
A Ulloa-Aguirre, T Zariñán, R Gutiérrez-Sagal… - Frontiers in …, 2022 - frontiersin.org
G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an
array of functions. Mutations in these receptors lead to a number of genetic diseases …
array of functions. Mutations in these receptors lead to a number of genetic diseases …
[HTML][HTML] Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER
Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction
X Xu, L Qiu, M Zhang, G Wu - Journal of Cell Science, 2024 - journals.biologists.com
ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …
surface signaling proteins that share a common structural topology. When compared with …
[HTML][HTML] Protocol to visualize and quantify the COPII concentration and anterograde transport of nascent G protein-coupled receptors
X Xu, G Wu - STAR protocols, 2024 - Elsevier
Here, we present a protocol for visualization and quantification of the recruitment of newly
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …
Part: BBa_K4875003
GT Part - parts.igem.org
The α2-adrenoceptor (α2-AR) family comprises α2A-, α2B-and α2C-AR subtypes [1-3],
which are expressed in presynaptic membranes of adrenergic neurons, where they act as …
which are expressed in presynaptic membranes of adrenergic neurons, where they act as …