Simple Summary Cells undergoing malignant transformation must circumvent replicative
senescence and eventual cell death associated with progressive telomere shortening that …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

SUMOylation is a post-translational modification that has emerged in recent decades as a
mechanism involved in controlling diverse physiological processes and that is essential in …

We applied raw human liver microsome lysate to a holey carbon grid and used cryo-electron
microscopy (cryo-EM) to define its composition. From this sample we identified and …

Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear
chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric …

Cancer survivors undergone treatment face an increased risk of developing atherosclerotic
cardiovascular disease (CVD), yet the underlying mechanisms remain elusive. Recent …

Simple Summary RAP1 (TERF2IP) is a member of the shelterin complex that protects
telomeric DNA and plays a critical role in maintaining chromosome stability. However …

The use of an integrated systems biology approach to investigate tissues and organs has
been thought to be impracticable in the field of structural biology, where the techniques …

All organisms depend on the ability of cells to accurately duplicate and segregate DNA into
progeny. However, DNA is frequently damaged by factors in the environment and from …

The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome
stability, most notably homologous recombination. Germline mutations in SLX4 are …