Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Systemic and local chronic inflammation might enhance the risk of pancreatic ductal
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …

Background We have previously discovered a relationship between the low expression of
protein tyrosine phosphatase, receptor type O (PTPRO) in tumor-infiltrating T cells and …

Gastrointestinal cancer (GI) is a major health problem. Patients with gastric, pancreatic,
colorectal, bile duct and gall bladder cancer often have advanced disease at the time of …

Pancreatic cancer has one of the poorest prognoses of all malignancies, with little
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …

The recreational use of methamphetamine (METH, or ice) is a global burden. It pervades
and plagues contemporary society; it has been estimated that there are up to 35 million …

In previous study, we got a purified ginger polysaccharide UGP1 and verified its significant
antitumor activities on colon cancer HCT116 cells. In this article, we aimed to illustrate the …

Hypoxic microenvironment and pancreatic stellate cells (PSCs) play important roles in
pancreatic cancer progression. PSCs secrete a number of soluble factors, such as …