Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in
metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group …

Although microbial genomes harbor an abundance of biosynthetic gene clusters, there
remain substantial technological gaps that impair the direct correlation of newly discovered …

Fungal polyketide–nonribosomal peptide (PK–NRP) hybrid macrolactones are a growing
family of natural products with biomedical and agricultural activities. One of the most …

Petroleum, as the “lifeblood” of industrial development, is the important energy source and
raw material. The selective transformation of petroleum into high‐end chemicals is of great …

Covering from 1992 to the end of 2020-11-20. Genetically-encoded polyenic macrolactams,
which are constructed by Nature using hybrid polyketide synthase/nonribosomal peptide …

Covering: up to 2020 Polyketides form a large group of bioactive secondary metabolites that
usually contain one or more double bonds. Although most of the double bonds found in …

Ribosomally synthesized and posttranslationally modified peptides (RiPPs) with polar-
functionalized fatty acyl groups are a rarely found untapped class of natural products …

Aspirochlorine is an unusual antifungal cyclopeptide produced by Aspergillus oryzae, an
important mold used for food fermentation. Whereas its structure suggested that a non …