Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

Human genetic studies of common variants have provided substantial insight into the
biological mechanisms that govern ovarian ageing. Here we report analyses of rare protein …

Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …

Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …

Low success rates during drug development are due, in part, to the difficulty of defining drug
mechanism‐of‐action and molecular markers of therapeutic activity. Here, we integrated …

Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor
rejection. However, cancer cells often evade these responses by overexpressing immune …

During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …

DNA double-strand breaks are a major threat to cellular survival and genetic integrity. In
addition to high fidelity repair, three intrinsically mutagenic DNA break repair routes have …