Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Structure and dynamics of a processive Brownian motor: the translating ribosome
J Frank, RL Gonzalez Jr - Annual review of biochemistry, 2010 - annualreviews.org
There is mounting evidence indicating that protein synthesis is driven and regulated by
mechanisms that direct stochastic, large-scale conformational fluctuations of the …
mechanisms that direct stochastic, large-scale conformational fluctuations of the …
On the importance of cotranscriptional RNA structure formation
D Lai, JR Proctor, IM Meyer - Rna, 2013 - rnajournal.cshlp.org
The expression of genes, both coding and noncoding, can be significantly influenced by
RNA structural features of their corresponding transcripts. There is by now mounting …
RNA structural features of their corresponding transcripts. There is by now mounting …
Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome
Background The understanding of RNA structure is a key feature toward the comprehension
of RNA functions and mechanisms of action. In particular, non-coding RNAs are thought to …
of RNA functions and mechanisms of action. In particular, non-coding RNAs are thought to …
Compact intermediates in RNA folding
SA Woodson - Annual review of biophysics, 2010 - annualreviews.org
Large noncoding RNAs fold into their biologically functional structures via compact yet
disordered intermediates, which couple the stable secondary structure of the RNA with the …
disordered intermediates, which couple the stable secondary structure of the RNA with the …
Nonredundant 3D structure datasets for RNA knowledge extraction and benchmarking
NB Leontis, CL Zirbel - RNA 3D structure analysis and prediction, 2012 - Springer
The continual improvement of methods for RNA 3D structure modeling and prediction
requires accurate and statistically meaningful data concerning RNA structure, both for …
requires accurate and statistically meaningful data concerning RNA structure, both for …
MEPSA: minimum energy pathway analysis for energy landscapes
From conformational studies to atomistic descriptions of enzymatic reactions, potential and
free energy landscapes can be used to describe biomolecular systems in detail. However …
free energy landscapes can be used to describe biomolecular systems in detail. However …
RNA editing: a driving force for adaptive evolution?
WM Gommans, SP Mullen, S Maas - Bioessays, 2009 - Wiley Online Library
Genetic variability is considered a key to the evolvability of species. The conversion of an
adenosine (A) to inosine (I) in primary RNA transcripts can result in an amino acid change in …
adenosine (A) to inosine (I) in primary RNA transcripts can result in an amino acid change in …
[HTML][HTML] Coarse-grained modeling of RNA 3D structure
WK Dawson, M Maciejczyk, EJ Jankowska, JM Bujnicki - Methods, 2016 - Elsevier
Functional RNA molecules depend on three-dimensional (3D) structures to carry out their
tasks within the cell. Understanding how these molecules interact to carry out their biological …
tasks within the cell. Understanding how these molecules interact to carry out their biological …
Taming free energy landscapes with RNA chaperones
SA Woodson - RNA biology, 2010 - Taylor & Francis
Many non-coding RNAs fold into complex three-dimensional structures, yet the self-
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …