Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Background Approximately two third of patients with a rare genetic disease remain
undiagnosed after exome sequencing (ES). As part of our post-test counseling procedures …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Mammalian genomes harbor abundant transposable elements (TEs) and their remnants,
with numerous epigenetic repression mechanisms enacted to silence TE transcription …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

Members of the NSL histone acetyltransferase complex are involved in multiorgan
developmental syndromes. While the NSL complex is known for its importance in early …

Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to
adaptive metabolic responses. Yet, how such functionally relevant protein acetylation is …