NaII and NaIIA channels are the most abundant voltage-gated channels in neonatal and
adult cortex, respectively. The relationships between activity and availability for activation of …

Neuropathic pain may be produced, at least in part, by the increased activity of primary
afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium …

The highly charged transmembrane segments in each of the four homologous domains
(S4D1–S4D4) represent the principal voltage sensors for sodium channel gating. Hitherto …

Non‐technical summary Muscle contraction is triggered by the spread of an action potential
along the fibre. The ionic current to generate the action potential is conducted through …

Whole-cell gating current recording from rat brain IIA sodium channels in Xenopus oocytes
was achieved using a high-expression system and a newly developed high-speed two …

Opening of ion-channels has been popularly described by means of Markov processes with
a small number of important channel states. The approximation of the number of important …

The physiology of voltage gated ion channels is complex and insights into their gating
mechanism is incomplete. Their function is best represented by Markov models with …

Mutations in SCN4A, the gene encoding the skeletal muscle Na+ channel (NaV1. 4) α-
subunit, cause several disorders related to skeletal muscle excitability. The functional …