The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
Beyond the X factor: relevance of sex hormones in NAFLD pathophysiology
S Della Torre - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being
frequently associated with obesity, unbalanced dietary regimens, and reduced physical …
frequently associated with obesity, unbalanced dietary regimens, and reduced physical …
[HTML][HTML] Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal …
H Zhang, A Wang, G Shen, X Wang, G Liu… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
As a necessary trace element, iron is involved in many physiological processes. Clinical and
basic studies have found that disturbances in iron metabolism, especially iron overload …
basic studies have found that disturbances in iron metabolism, especially iron overload …
Variation in expression of cytochrome P450 3A isoforms and toxicological effects: endo-and exogenous substances as regulatory factors and substrates
C Fujino, S Sanoh, T Katsura - Biological and Pharmaceutical …, 2021 - jstage.jst.go.jp
The CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans,
plays important roles in the metabolism of various endogenous and exogenous substances …
plays important roles in the metabolism of various endogenous and exogenous substances …
Licorice ameliorates cisplatin-induced hepatotoxicity through antiapoptosis, antioxidative stress, anti-inflammation, and acceleration of metabolism
Q Man, Y Deng, P Li, J Ma, Z Yang, X Yang… - Frontiers in …, 2020 - frontiersin.org
Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious
adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a …
adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a …
The effects of estrogen on targeted cancer therapy drugs
Y Zhao, X Wang, Y Liu, HY Wang, J Xiang - Pharmacological Research, 2022 - Elsevier
Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex
hormone that not only promotes the development of female secondary sexual …
hormone that not only promotes the development of female secondary sexual …
Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
L Zhou, AD Montalvo, JM Collins… - Pharmacology Research …, 2023 - Wiley Online Library
UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play
important roles in the detoxification of endogenous and exogenous substrates. The 22 …
important roles in the detoxification of endogenous and exogenous substrates. The 22 …
Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes …
Cytochrome P450 (CYP) drug metabolizing enzymes are responsible for the metabolism of
over 70% of currently used medications with the CYP3A family being the most important …
over 70% of currently used medications with the CYP3A family being the most important …
Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1
JM Collins, D Wang - Drug metabolism and personalized therapy, 2021 - degruyter.com
Objectives The function and expression of cytochrome P450 (CYP) drug metabolizing
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …
enzymes is highly variable, greatly affecting drug exposure, and therapeutic outcomes. The …
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization
JM Collins, D Wang - Journal of pharmacological and toxicological …, 2021 - Elsevier
The western blot (WB) is the predominate method for protein quantification, frequently used
in pharmacological and toxicological studies. To control for technical variation, WB signals …
in pharmacological and toxicological studies. To control for technical variation, WB signals …