The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

Over a quarter of the workforce in industrialized countries does shift work, which increases
the risk for cardiometabolic disease. Yet shift workers are often excluded from lifestyle …

The various non-standard schedules required of shift workers force abrupt changes in the
timing of sleep and light-dark exposure. These changes result in disturbances of the …

The metabolic syndrome is prevalent in developed nations and accounts for the largest
burden of non-communicable diseases worldwide. The metabolic syndrome has direct …

The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

Daylight stems solely from direct, scattered and reflected sunlight, and undergoes dynamic
changes in irradiance and spectral power composition due to latitude, time of day, time of …

Highlights•Energy expenditure, substrate oxidation, and appetite follow circadian
rhythms.•Mistimed eating and sleeping disrupt circadian rhythms, increasing risk of …

Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …

Shift work, defined as work occurring outside typical daytime working hours, is associated
with an increased risk for metabolic syndrome (MetS) due to several biological and …