Applications of palladium-catalyzed C–N cross-coupling reactions
P Ruiz-Castillo, SL Buchwald - Chemical reviews, 2016 - ACS Publications
Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to
synthesize anilines and aniline derivatives, an important class of compounds throughout …
synthesize anilines and aniline derivatives, an important class of compounds throughout …
Inhibiting conjugation as a tool in the fight against antibiotic resistance
Antibiotic resistance, especially in gram‐negative bacteria, is spreading globally and rapidly.
Development of new antibiotics lags behind; therefore, novel approaches to the problem of …
Development of new antibiotics lags behind; therefore, novel approaches to the problem of …
Natural and artificial strategies to control the conjugative transmission of plasmids
M Getino, F de la Cruz - Microbiology spectrum, 2018 - Am Soc Microbiol
Conjugative plasmids are the main carriers of transmissible antibiotic resistance (AbR)
genes. For that reason, strategies to control plasmid transmission have been proposed as …
genes. For that reason, strategies to control plasmid transmission have been proposed as …
Possible drugs for the treatment of bacterial infections in the future: anti-virulence drugs
H Ogawara - The Journal of antibiotics, 2021 - nature.com
Antibiotic resistance is a global threat that should be urgently resolved. Finding a new
antibiotic is one way, whereas the repression of the dissemination of virulent pathogenic …
antibiotic is one way, whereas the repression of the dissemination of virulent pathogenic …
Future Perspective for Potential Helicobacter Pylori Eradication Therapies
A Debraekeleer, H Remaut - Future microbiology, 2018 - Taylor & Francis
Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …
Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds
R Emadi, AB Nekoo, F Molaverdi, Z Khorsandi… - RSC …, 2023 - pubs.rsc.org
C–N cross-coupling bond formation reactions have become valuable approaches to
synthesizing anilines and their derivatives, known as important chemical compounds …
synthesizing anilines and their derivatives, known as important chemical compounds …
Type IV coupling proteins as potential targets to control the dissemination of antibiotic resistance
I Álvarez-Rodríguez, L Arana… - Frontiers in Molecular …, 2020 - frontiersin.org
The increase of infections caused by multidrug-resistant bacteria, together with the loss of
effectiveness of currently available antibiotics, represents one of the most serious threats to …
effectiveness of currently available antibiotics, represents one of the most serious threats to …
The role of bacterial secretion systems in the virulence of gram-negative airway pathogens associated with cystic fibrosis
S Depluverez, S Devos, B Devreese - Frontiers in microbiology, 2016 - frontiersin.org
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused
by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the …
by mutation of the CF transmembrane conductance regulator (CFTR) gene. A defect in the …
Targeting bacterial pathogenesis by inhibiting virulence-associated Type III and Type IV secretion systems
N Blasey, D Rehrmann, AK Riebisch… - Frontiers in Cellular and …, 2023 - frontiersin.org
Infections caused by Gram-negative pathogens pose a major health burden. Both
respiratory and gastrointestinal infections are commonly associated with these pathogens …
respiratory and gastrointestinal infections are commonly associated with these pathogens …
Peptidomimetic small molecules disrupt type IV secretion system activity in diverse bacterial pathogens
CL Shaffer, JAD Good, S Kumar, KS Krishnan… - MBio, 2016 - Am Soc Microbiol
Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector
proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis …
proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis …