Ursolic acid and its derivatives as bioactive agents

S Mlala, AO Oyedeji, M Gondwe, OO Oyedeji - Molecules, 2019 - mdpi.com
Non-communicable diseases (NCDs) such as cancer, diabetes, and chronic respiratory and
cardiovascular diseases continue to be threatening and deadly to human kind. Resistance …

Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

S Ali, M Alam, F Khatoon, U Fatima, AM Elasbali… - Biomedicine & …, 2022 - Elsevier
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …

[PDF][PDF] Ursolic acid in health and disease

DY Seo, SR Lee, JW Heo, MH No… - The Korean journal …, 2018 - synapse.koreamed.org
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables.
There is a growing interest in UA because of its beneficial effects, which include anti …

Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer

H Li, Y Yu, Y Liu, Z Luo, BYK Law, Y Zheng… - Pharmacological …, 2022 - Elsevier
As a broad-spectrum oral small molecule inhibitor targeting multikinase, sorafenib is
currently approved for the clinical treatment of several types of cancer as a single agent. A …

Biological and pharmacological effects of synthetic saponins

YP Juang, PH Liang - Molecules, 2020 - mdpi.com
Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or
steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal …

Immunomodulatory properties of triterpenes

G Renda, İ Gökkaya, D Şöhretoğlu - Phytochemistry Reviews, 2022 - Springer
The immune system is one of the main defence mechanisms of the human body.
Inadequacy of this system or immunodeficiency results in increased risk of infections and …

The role of Platinum (IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022

S Su, Y Chen, P Zhang, R Ma, W Zhang, J Liu… - European Journal of …, 2022 - Elsevier
Platinum-based antitumor drugs have been used in many types of tumors due to its broad
antitumor spectrum in clinic. Encouraged by the cisplatin's (CDDP) worldwide success in …

Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research

J Hodon, L Borkova, J Pokorny, A Kazakova… - European journal of …, 2019 - Elsevier
Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …

The possible role of ursolic acid in Covid-19: a real game changer

HM Al-Kuraishy, AI Al-Gareeb, GES Batiha - Clinical nutrition ESPEN, 2022 - Elsevier
Ursolic acid (UA) is a pentacyclic terpenoid is usually found in the fruit peels and stem bark
as secondary metabolites. UA has antiviral, antibacterial, and antiparasitic properties. UA …

A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

Y Zhang, X Li, B Ciric, MT Curtis… - Proceedings of the …, 2020 - National Acad Sciences
Current multiple sclerosis (MS) medications are mainly immunomodulatory, having little or
no effect on neuroregeneration of damaged central nervous system (CNS) tissue; they are …