RBG motif bridge-like lipid transport proteins: structure, functions, and open questions
M Hanna, A Guillén-Samander… - Annual Review of Cell …, 2023 - annualreviews.org
The life of eukaryotic cells requires the transport of lipids between membranes, which are
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the …
The genetic architecture of Parkinson's disease
Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …
common genetic variants contribute to disease risk, onset, and progression. Mutations in …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …
increased the scope of biological knowledge about the disease over the past decade. We …
Genetics of Parkinson's disease: an introspection of its journey towards precision medicine
S Bandres-Ciga, M Diez-Fairen, JJ Kim… - Neurobiology of …, 2020 - Elsevier
ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …
Initiation and propagation of α-synuclein aggregation in the nervous system
BA Hijaz, LA Volpicelli-Daley - Molecular neurodegeneration, 2020 - Springer
The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
DC Berwick, GR Heaton, S Azeggagh… - Molecular …, 2019 - Springer
Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …
Multi-ancestry genome-wide association meta-analysis of Parkinson's disease
Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …
using genome-wide association studies, most studies have been performed in just one …
Cerebrospinal fluid biomarkers of synaptic dysfunction are altered in Parkinson's disease and related disorders
J Nilsson, J Constantinescu, B Nellgård… - Movement …, 2023 - Wiley Online Library
Background Synaptic dysfunction and degeneration are central contributors to the
pathogenesis and progression of parkinsonian disorders. Therefore, identification and …
pathogenesis and progression of parkinsonian disorders. Therefore, identification and …
Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?
While current effective therapies are available for the symptomatic control of PD, treatments
to halt the progressive neurodegeneration still do not exist. Loss of dopamine neurons in the …
to halt the progressive neurodegeneration still do not exist. Loss of dopamine neurons in the …