Antipsychotic-induced alterations in lipid turnover

S Pereira, E Au, SM Agarwal, DC Wright… - Endocrinology, 2023 - academic.oup.com
Schizophrenia is a debilitating psychiatric disorder that is treated with antipsychotics.
However, despite their efficacy, antipsychotics increase the risk of metabolic disorders in a …

The gut microbiome in schizophrenia and the potential benefits of prebiotic and probiotic treatment

JCW Liu, I Gorbovskaya, MK Hahn, DJ Müller - Nutrients, 2021 - mdpi.com
The gut microbiome (GMB) plays an important role in developmental processes and has
been implicated in the etiology of psychiatric disorders. However, the relationship between …

Adiposity in schizophrenia: a systematic review and meta‐analysis

E Smith, R Singh, J Lee, L Colucci… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective Although a relationship between schizophrenia (SCZ), antipsychotic (AP)
medication, and metabolic dysregulation is now well established, the effect of adiposity is …

Neuropharmacology of organoselenium compounds in mental disorders and degenerative diseases

PT Birmann, AM Casaril, L Abenante… - Current Medicinal …, 2023 - benthamdirect.com
Neurodegenerative and mental disorders are a public health burden with pharmacological
treatments of limited efficacy. Organoselenium compounds are receiving great attention in …

Antipsychotic-induced metabolic syndrome: a review

PS Akinola, I Tardif, J Leclerc - Metabolic Syndrome and Related …, 2023 - liebertpub.com
Schizophrenia, a serious psychiatric disorder, is among the top 10 global causes of disability
and affects nearly 1% of the world population. Antipsychotics constitute the best treatment for …

Alternative therapy of psychosis: Potential phytochemicals and drug targets in the management of schizophrenia

A Saleem, MF Akhtar - Frontiers in pharmacology, 2022 - frontiersin.org
Schizophrenia is a chronic mental and behavioral disorder characterized by clusters of
symptoms including hallucinations, delusions, disorganized thoughts and social withdrawal …

A marked low-grade inflammation and a significant deterioration in metabolic status in first-episode schizophrenia: a five-year follow-up study

M Parksepp, L Haring, K Kilk, E Taalberg, R Kangro… - Metabolites, 2022 - mdpi.com
The objective of this study was to evaluate how schizophrenia spectrum disorders and
applied long-term (5.1 years) antipsychotic (AP) treatment affect the serum level of …

Shared biological pathways between antipsychotics and omega-3 fatty acids: a key feature for schizophrenia preventive treatment?

A Frajerman, L Scoriels, O Kebir… - International Journal of …, 2021 - mdpi.com
Schizophrenia typically emerges during adolescence, with progression from an ultra-high
risk state (UHR) to the first episode of psychosis (FEP) followed by a chronic phase. The …

The expression of immune related genes and potential regulatory mechanisms in schizophrenia

S Yu, Y Qu, Z Du, M Ou, R Lu, J Yuan, Y Jiang… - Schizophrenia …, 2024 - Elsevier
Objective This study aimed to investigate the role of immune dysfunction in the pathogenesis
of schizophrenia through single-cell transcriptome and bulk RNA data analyses. Methods …

Central insulin dysregulation in antipsychotic-naïve first-episode psychosis: In silico exploration of gene expression signatures

J Lee, X Xue, E Au, WB McIntyre, R Asgariroozbehani… - Psychiatry …, 2024 - Elsevier
Antipsychotic drug (AP)-naïve first-episode psychosis (FEP) patients display premorbid
cognitive dysfunctions and dysglycemia. Brain insulin resistance may link metabolic and …