Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

The heat-shock response is a mechanism of cellular protection against sudden adverse
environmental growth conditions and results in the prompt production of various heat-shock …

Protein turnover is a tightly controlled process that is crucial for the removal of aberrant
polypeptides and for cellular signalling. Whereas ubiquitin marks eukaryotic proteins for …

Intracellular proteolysis carried out by energy-dependent proteases is one of the most
conserved biological processes. In all cells proteolysis maintains and shapes the cellular …

Expression of all Yersinia pathogenicity factors encoded on the virulence plasmid, including
the yop effector and the ysc type III secretion genes, is controlled by the transcriptional …

Protein modifications not only affect protein homeostasis but can also establish new cellular
protein functions and are important components of complex cellular signal sensing and …

Reversible protein phosphorylation is an important and ubiquitous protein modification in all
living cells. Here we report that protein phosphorylation on arginine residues plays a …

Bacillus subtilis cells are well suited to study how bacteria sense and adapt to proteotoxic
stress such as heat, since temperature fluctuations are a major challenge to soil-dwelling …

Fast adaptation to environmental changes ensures bacterial survival, and proteolysis
represents a key cellular process in adaptation. The Clp protease system is a multi …