Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

MC Chappell - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Bioanalytical approaches to analyzing peptides and proteins by LC–MS/MS

M Ewles, L Goodwin - Bioanalysis, 2011 - Taylor & Francis
Peptides and proteins have been utilized as therapeutic agents for over 40 years. Traditional
approaches to quantify these molecules in biological matrices have utilized immunoassay …

Diversity of neuropeptide cell-cell signaling molecules generated by proteolytic processing revealed by neuropeptidomics mass spectrometry

V Hook, CB Lietz, S Podvin, T Cajka… - Journal of the American …, 2018 - ACS Publications
Neuropeptides are short peptides in the range of 3–40 residues that are secreted for cell-cell
communication in neuroendocrine systems. In the nervous system, neuropeptides comprise …

Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney

N Grobe, KM Elased, DR Cool… - American Journal of …, 2012 - journals.physiology.org
To better understand the tissue distribution and activity of enzymes involved in angiotensin II
(Ang II) processing, we developed a novel molecular imaging method using matrix-assisted …

A microanalytical capillary electrophoresis mass spectrometry assay for quantifying angiotensin peptides in the brain

C Lombard-Banek, Z Yu, AP Swiercz, PJ Marvar… - Analytical and …, 2019 - Springer
The renin-angiotensin system (RAS) of the brain produces a series of biologically active
angiotensinogen-derived peptides involved in physiological homeostasis and …

Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform

AD Tinoco, DM Tagore… - Journal of the American …, 2010 - ACS Publications
In recent years, the biological sciences have seen a surge in the development of methods,
including high-throughput global methods, for the quantitative measurement of biomolecule …

An electrochemical aptasensor for chiral peptide detection using layer-by-layer assembly of polyelectrolyte-methylene blue/polyelectrolyte-graphene multilayer

H Qin, J Liu, C Chen, JH Wang, E Wang - Analytica chimica acta, 2012 - Elsevier
Here we demonstrate for the first time that by physically adsorbing aptamer onto conductive
film assembled via alternate adsorption of graphene/polyelectrolyte and methylene …

Perspectives for angiotensin profiling with liquid chromatography/mass spectrometry to evaluate ACE/ACE2 balance in endothelial dysfunction and vascular …

M Olkowicz, S Chlopicki, RT Smolenski - Pharmacological Reports, 2015 - Springer
Vascular injury, characterized by endothelial dysfunction, inflammation, structural
remodeling, thrombosis and calcification leads to cardiovascular diseases. Angiotensin …

Neuropeptidomics mass spectrometry reveals signaling networks generated by distinct protease pathways in human systems

V Hook, N Bandeira - Journal of the American Society for Mass …, 2015 - ACS Publications
Neuropeptides regulate intercellular signaling as neurotransmitters of the central and
peripheral nervous systems, and as peptide hormones in the endocrine system. Diverse …