Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) …

A Beckers, LA Aaltonen, AF Daly, A Karhu - Endocrine reviews, 2013 - academic.oup.com
Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma

Y Zhou, X Zhang, A Klibanski - Molecular and cellular endocrinology, 2014 - Elsevier
Human pituitary adenomas are the most common intracranial neoplasms. Approximately 5%
of them are familial adenomas. Patients with familial tumors carry germline mutations in …

Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers

LC Hernández-Ramírez, P Gabrovska… - The Journal of …, 2015 - academic.oup.com
Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor
interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete …

The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas

CA Leontiou, M Gueorguiev… - The Journal of …, 2008 - academic.oup.com
Context: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein
(AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this …

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families

S Igreja, HS Chahal, P King, GB Bolger… - Human …, 2010 - Wiley Online Library
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable
genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon …

AIP expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of SSTR2 expression

L Kasuki, LV Neto, LEA Wildemberg… - Endocrine-Related …, 2012 - erc.bioscientifica.com
It is generally accepted that women with breast cancer (BC) have an increased risk of
venous thromboembolism (VTE) compared with age-matched women without cancer …

Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA)

HS Chahal, JP Chapple, LA Frohman… - Trends in Endocrinology …, 2010 - cell.com
Familial pituitary adenomas can occur in MEN1 and Carney complex, as well as in the
recently characterized familial isolated pituitary adenoma (FIPA) syndrome. FIPA is an …

MEN1, MEN4, and carney complex: pathology and molecular genetics

MH Schernthaner-Reiter, G Trivellin… - Neuroendocrinology, 2016 - karger.com
Pituitary adenomas are a common feature of a subset of endocrine neoplasia syndromes,
which have otherwise highly variable disease manifestations. We provide here a review of …

Genetic mutations in sporadic pituitary adenomas—what to screen for?

AL Lecoq, P Kamenický, A Guiochon-Mantel… - Nature Reviews …, 2015 - nature.com
Pituitary adenomas are benign intracranial neoplasms that can result in morbidity owing to
local invasion and/or excessive or deficient hormone production. The prevalence of …

The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway

GB Bolger - Frontiers in Endocrinology, 2022 - frontiersin.org
The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations
in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range …