Over the past decade, there have been numerous advances in our understanding of the
molecular pathogenesis of tuberous sclerosis complex (TSC). Following the identification of …

Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development
because the genes that cause TSC are known, many downstream molecular pathways have …

Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant neurocutaneous
disorder secondary to mutations in the TSC1 or TSC2 tumor suppressor genes. Although …

Epilepsy is one of the most common neurologic disorders, affecting about 50 million people
worldwide. The disease is characterized by recurrent seizures, which are due to aberrant …

Neonatal period is the most vulnerable time for the occurrence of seizures, and neonatal
seizures often pose a clinical challenge both for their acute management and frequency of …

Focal cortical dysplasias are common malformations of cerebral cortical development and
are highly associated with medically intractable epilepsy. They have been classified into …

Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated
with severe intractable epilepsy. In some TSC patients epilepsy surgery is a promising …

Structural abnormalities of the brain are increasingly recognized in patients with
neurodevelopmental delay and intractable focal epilepsies. The access to clinically well …

Quantitative magnetic resonance imaging (MRI) with multislice, multi-echo, and multi-delay
acquisition enables simultaneous quantification of R 1 and R 2 relaxation rates, proton …

Objective In tuberous sclerosis complex (TSC)‐associated drug‐resistant epilepsy, the
optimal invasive electroencephalographic (EEG) and operative approach remains unclear …