Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Ziconotide (ZIC) is an N-type calcium channel antagonist for treating severe chronic pain
that is intolerable, or responds poorly to the administration of other drugs, such as intrathecal …

Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat
conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with …

A rotigotine (ROT)-loaded polymer micelles thermosensitive gel (ROT-PM-TSG) delivery
system was engineered to enhance the solubility of the drug, prolong the residence time …

Background. The aim of the present study was to assess the effects of lavender oil inhalation
on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in …

The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally
believed unidirectional and constant CSF circulation, has been demonstrated. In the present …

Mucoadhesive in situ gelling systems (soluble gels) have received considerable attention
recently as effective stimuli-transforming vectors for a range of drug delivery applications …