1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

The oxidation of lipids has long been a topic of interest in biological and food sciences, and
the fundamental principles of non-enzymatic free radical attack on phospholipids are well …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely
deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the …

Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …

Background—Lipoprotein-associated phospholipase A2 (Lp-PLA2) is expressed abundantly
in the necrotic core of coronary lesions, and products of its enzymatic activity may contribute …

Lysophosphatidylcholine (LPC) is a major plasma lipid that has been recognized as an
important cell signalling molecule produced under physiological conditions by the action of …

Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity is associated with
increased risk of cardiac events, but it is not known whether Lp-PLA2 is a causative agent …

Lipidomics has developed rapidly over the past decade to the point where clinical
application may soon be possible. Developments including high throughput technologies …