Assessments of population genetic structure have become an increasing focus as they can
provide valuable insight into patterns of migration and gene flow. structure, the most highly …

Abstract “Conservation genomics” encompasses the idea that genome-scale data will
improve the capacity of resource managers to protect species. Although genetic approaches …

Many contemporary large-scale applications involve building interpretable models linking a
large set of potential covariates to a response in a non-linear fashion, such as when the …

A common method of minimizing errors in large DNA sequence data sets is to drop variable
sites with a minor allele frequency (MAF) below some specified threshold. Although …

Local-ancestry inference is an important step in the genetic analysis of fully sequenced
human genomes. Current methods can only detect continental-level ancestry (ie, European …

Population stratification has long been recognized as a confounding factor in genetic
association studies. Estimated ancestries, derived from multi-locus genotype data, can be …

The advent of genome-wide dense variation data provides an opportunity to investigate
ancestry in unprecedented detail, but presents new statistical challenges. We propose a …

Non-communicable diseases, including cancer, are overtaking infectious disease as the
leading health-care threat in middle-income and low-income countries. Latin American and …

Understanding the genetic structure of human populations is of fundamental interest to
medical, forensic and anthropological sciences. Advances in high-throughput genotyping …

Long-range migrations and the resulting admixtures between populations have been
important forces shaping human genetic diversity. Most existing methods for detecting and …