Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

Natural products containing eight-membered carbocycles constitute a class of structurally
intriguing and biologically important molecules such as the famous diterpenes taxol and …

Taxol (a brand name for paclitaxel) is widely regarded as among the most famed natural
isolates ever discovered, and has been the subject of innumerable studies in both basic and …

Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …

Paclitaxel is the first microtubule-stabilizing agent identified and considered to be the most
significant advance in chemotherapy of the past two decades. It is considered one of the …

Taxol is one of the most famous natural diterpenoids and an important anticancer medicine.
Taxol represents a formidable synthetic challenge and has prompted significant interest from …

Chemical synthesis of natural products is typically inspired by the structure and function of a
target molecule. When both factors are of interest, such as in the case of taxane …

This Perspective goes into the fine details of our laboratory's quest to answer a longstanding
fundamental question: Could any new approach to terpene synthesis, perhaps one …

Asymmetric catalysis for chiral compound synthesis is a rapidly growing field in modern
organic chemistry and provides enantioselective materials to meet the demands of various …

Seven-and eight-membered rings widely exist in natural products and drugs. Considering
the transition state nonbonding interactions and torsional strains, the flexible conformations …