The devastating pandemic of coronavirus disease 2019 (COVID-19) has caused thousands
of deaths and left millions of restless patients suffering from its complications. Increasing …

The maintenance of cellular cholesterol homeostasis is essential for normal cell function and
viability. Excessive cholesterol accumulation is detrimental to cells and serves as the …

The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, of which
the occurrence and development involve a variety of pathophysiological processes, such as …

Peritoneal dialysis is an efficient renal replacement therapy for patients with end-stage
kidney disease. However, continuous exposure of the peritoneal membrane to dialysate …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes enhanced
mortality in people with metabolic and cardiovascular diseases. Other highly infectious RNA …

Cholesterol in the circulation is mostly transported in an esterified form as a component of
lipoproteins. The majority of these cholesteryl esters are produced in nascent, discoidal high …

Objective Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1)
influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been especially
devastating to patients with comorbidities, including metabolic and cardiovascular diseases …